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Treatment Outcomes in Patients with Recurrent Adrenocortical Carcinoma
Tamara Dojcinovic1,2, Karin Zibar Tomsic3, Ivana Dora Vodanovic3
1Department of Endocrinology of the Internal medicine clinic, University Clinical Centre of the Republic of Srpska, Banja Luka, Bosnia and Herzegovina.
Endocrine Research
|September 2, 2024
Summary
Recurrent adrenocortical carcinoma (ACC) treatment outcomes show that while many patients face progression, diverse therapies can lead to long-term survival. Advanced age and shorter recurrence intervals are linked to increased mortality in ACC patients.
Area of Science:
- Endocrinology
- Oncology
- Surgical Oncology
Background:
- Limited data exists on treatment outcomes for patients with recurrent adrenocortical carcinoma (ACC).
- Understanding outcomes in this specific subpopulation is crucial for improving patient care.
Purpose of the Study:
- To assess treatment outcomes in patients diagnosed with recurrent adrenocortical carcinoma (ACC).
Main Methods:
- Retrospective study including 18 patients with recurrent ENSAT stage I-III ACC.
- Patients underwent R0 or Rx surgical resection.
- Median follow-up after recurrence was 32 months.
Main Results:
- Median time to recurrence was 29 months, with 61% developing distant metastases.
- Treatments included repeat surgery, chemotherapy, mitotane, and radiotherapy.
- Median progression-free survival (PFS) was 17 months; overall survival (OS) was not reached.
- Advanced age and shorter interval to recurrence were associated with increased mortality.
Conclusions:
- A significant proportion of patients with recurrent ACC experience disease progression.
- Integrating diverse treatment modalities offers potential for long-term survival in recurrent ACC patients.
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