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A morpho-viscoelasticity theory for growth in proliferating aggregates
Prakhar Bandil1, Franck J Vernerey2
1Department of Mechanical Engineering, University of Colorado, Boulder, USA.
Biomechanics and Modeling in Mechanobiology
|September 2, 2024
Summary
This study introduces a new multiscale model to simulate biological growth in 3D tissues. It accounts for cell division, expansion, and intercalation, improving models of proliferating aggregates like organoids.
Area of Science:
- Continuum mechanics
- Multiscale modeling
- Developmental biology
Background:
- Existing models overlook cell-level morphogenetic behaviors in active growth dynamics.
- Challenges exist in continuum treatment of cell division and expansion for growth modeling.
- Current models are limited to 2D and not extended to 3D multicellular systems.
Purpose of the Study:
- To present a generalized multiscale model for 3D biological growth.
- To incorporate cell division, expansion, and intercalation into continuum theory.
- To enable comprehensive exploration of growth and dissipation mechanics in proliferating aggregates.
Main Methods:
- Developed a generalized multiscale continuum model.
- Extended modeling capabilities to three-dimensional multicellular systems.
- Integrated cell division, expansion, and intercalation processes.
Main Results:
- The model accounts for complex morphogenetic movements in 3D aggregates.
- Enables detailed study of growth dynamics in proliferating tissues.
- Provides a framework for analyzing dissipation mechanics during growth.
Conclusions:
- The proposed model addresses limitations in current biological growth simulations.
- It offers a comprehensive approach to modeling 3D multicellular growth.
- Facilitates deeper understanding of organoid and spheroid development.
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