Enzyme-responsive, multi-lock optical probes for molecular imaging and disease theranostics
Penghui Cheng1, Kanyi Pu1,2
1School of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, 70 Nanyang Drive, 637457 Singapore, Singapore. kypu@ntu.edu.sg.
Chemical Society Reviews
|September 4, 2024
Summary
Multi-lock activatable optical probes (MOPs) offer improved disease diagnosis specificity over single-lock probes by detecting multiple biomarkers. This enhances accuracy and efficacy in image-guided therapies with reduced toxicity.
Area of Science:
- Biomedical Imaging
- Molecular Diagnostics
- Optical Probe Technology
Background:
- Optical imaging enables non-invasive visualization of biomolecules for disease diagnosis and treatment.
- Single-lock activatable optical probes (SOPs) enhance sensitivity but can yield false positives due to non-specific biomarker expression.
- Multi-lock activatable optical probes (MOPs) offer improved specificity by targeting multiple biomarkers simultaneously.
Purpose of the Study:
- To review advancements in enzyme-responsive multi-lock activatable optical probes (MOPs).
- To highlight the biomedical applications of MOPs.
- To discuss challenges and future directions for MOPs in disease diagnosis and therapy.
Main Methods:
- Review of recent literature on enzyme-responsive MOPs.
- Focus on MOPs' mechanism for enhanced specificity.
- Analysis of MOPs' performance in biomedical applications.
Main Results:
- MOPs demonstrate superior detection specificity compared to SOPs.
- Simultaneous detection of multiple biomarkers by MOPs reduces false-positive diagnoses.
- MOPs improve accuracy in disease diagnosis and image-guided therapy.
Conclusions:
- MOPs enhance disease diagnosis accuracy and treatment efficacy.
- MOPs minimize toxicity to surrounding healthy tissues.
- Further research into MOPs holds promise for advanced biomedical applications.
