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Related Concept Videos

Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

329
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
329
Drug Delivery: Overview01:16

Drug Delivery: Overview

279
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
279
Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

395
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
395
Non-Oral Extravascular Drug Absorption Routes01:15

Non-Oral Extravascular Drug Absorption Routes

207
Non-oral extravascular routes, which encompass sublingual, buccal, topical, intramuscular, and inhalation methods, primarily utilize passive diffusion to transport drugs into the systemic circulation. The absorption rates and effectiveness of these routes depend on the drug's physicochemical properties, as well as the patient's anatomical and pathophysiological state.
Lipophilic drugs that are stable at salivary pH (6) and exhibit minimal binding to the oral mucosa are absorbed more...
207
Routes of Drug Administration: Enteral01:18

Routes of Drug Administration: Enteral

3.4K
Medications can be administered through the enteral route using liquids, capsules, or tablets.
Enteral administration involves drug administration via the mouth in two ways: orally or sublingually.
Unlike sublingually drugs, drugs that are taken orally pass through the gastrointestinal (GI) tract and get metabolized by the liver. Once metabolized, the drug is absorbed into the systemic circulation, reaching different body parts via the bloodstream. However, while passing through the stomach,...
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Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

179
Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
179

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Related Experiment Video

Updated: Jun 14, 2025

Development and Characterization of Fusidic Acid-Loaded Alginate-Aloe vera Based Hydrogel FilmWound Healing
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Development and Characterization of Fusidic Acid-Loaded Alginate-Aloe vera Based Hydrogel FilmWound Healing

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Oral Patch/Film for Drug Delivery-Current Status and Future Prospects.

Yujie Yan1, Wenjie Yan2, Sihua Wu1

  • 1State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Research Unit of Oral Carcinogenesis and Management & Chinese Academy of Medical Sciences, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

Biopolymers
|September 4, 2024
PubMed
Summary

Oral patches and films offer a convenient, noninvasive method for drug delivery, enhancing bioavailability and patient compliance. This review explores their design, manufacturing, and applications for localized and systemic treatments.

Keywords:
biocompatible materialsdrug delivery systemspatient comforttissue adhesivestopical administrations

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Spatio-Temporal In Vivo Imaging of Ocular Drug Delivery Systems using Fiberoptic Confocal Laser Microendoscopy
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Area of Science:

  • Pharmaceutical Sciences
  • Biomaterials Science
  • Drug Delivery Systems

Background:

  • Extensive research focuses on drug delivery systems to improve drug efficacy and reduce toxicity.
  • Oral patches/films are gaining attention for their convenience and noninvasive administration.
  • These systems bypass hepatic first-pass metabolism, potentially increasing drug bioavailability.

Purpose of the Study:

  • To review oral patch/film technology from an anatomical and drug delivery perspective.
  • To illustrate design concepts, manufacturing techniques, and ideal attributes of oral patches/films.
  • To discuss applications in localized and systemic drug delivery and future prospects.

Main Methods:

  • Literature review focusing on oral cavity anatomy and drug delivery challenges.
  • Analysis of design principles, manufacturing methods, and research approaches for oral films/patches.
  • Discussion of existing and potential applications in drug delivery.

Main Results:

  • Oral patches/films present advantages like enhanced bioavailability and improved patient compliance.
  • The review details design considerations, manufacturing processes, and ideal characteristics for oral patches/films.
  • Applications span both localized oral treatments and systemic drug delivery.

Conclusions:

  • Oral patches/films represent a promising drug delivery system with significant advantages.
  • Further research and development can optimize their use for both localized and systemic drug delivery.
  • This technology holds potential for advancing oral drug delivery systems, especially for specific patient groups.