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Updated: Jun 14, 2025

Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures

Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures

Published on: January 9, 2019

Caspase 3 Expression Profiles in Meningioma Subtypes Based on Tissue Microarray Analysis.

Dimitrios Roukas¹, Evangelos Tsiambas^2,3, Despoina Spyropoulou⁴

¹Department of Psychiatry, 417 Veterans Army (NIMTS) Hospital, Athens, Greece.

Cancer Diagnosis & Prognosis

|September 6, 2024

Summary

This summary is machine-generated.

Low caspase 3 protein expression in meningiomas correlates with tumor grade and mitotic activity. Enhancing caspase 3 activity may offer new therapeutic strategies for these common brain tumors.

Keywords:

Meningioma apoptosis caspase immunohistochemistry

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Last Updated: Jun 14, 2025

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Published on: October 4, 2019

Area of Science:

Neuro-oncology
Molecular pathology
Cancer biology

Background:

Meningiomas are the most common primary central nervous system tumors in adults globally.
Apoptotic pathway dysregulation in malignancies, including meningiomas, is linked to chemoresistance and poor prognosis.
Caspases are key proteins mediating programmed cell death (apoptosis).

Purpose of the Study:

To investigate the correlation between caspase 3 protein expression levels and the clinicopathological features of meningiomas.
To analyze the relationship between caspase 3 expression and tumor grade, mitotic index, and histopathological subtype.

Main Methods:

Analysis of 50 meningioma lesions across various histopathological subtypes.
Immunohistochemistry using an anti-caspase 3 antibody on tissue microarray cores.
Image analysis of immunostained slides to quantify caspase 3 expression.

Main Results:

Caspase 3 over-expression was observed in 34% (17/50) of cases; 66% showed medium to low levels.
Caspase 3 expression significantly correlated with tumor grade (p=0.002) and mitotic index (p=0.001).
A significant correlation was also found between caspase 3 expression status and meningioma histotype (p=0.016).

Conclusions:

Low caspase 3 expression in a substantial subset of meningiomas is associated with differentiation grade, mitotic activity, and specific histotypes.
Therapeutic strategies targeting agents that enhance caspase 3 expression and apoptotic activity hold promise for novel oncology treatments.