Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

What is Cell Signaling?02:03

What is Cell Signaling?

116.4K
Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate to respond to the environment.
116.4K
Contact-dependent Signaling01:19

Contact-dependent Signaling

44.5K
Contact-dependent signaling, as the name suggests, requires that communicating cells be in direct contact with each other. This is achieved either through receptor-ligand interactions or by specialized cytoplasmic channels that allow the flow of small molecules between cells. In animal cells, channels called gap junctions facilitate contact-dependent signaling in certain tissues, whereas, plasmodesmata perform a similar function in plants.
Gap Junctions
In animal cells, gap junctions are formed...
44.5K
Overview of Cell Signaling01:23

Overview of Cell Signaling

20.2K
Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate with the environment.
Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...
20.2K
Autocrine Signaling01:01

Autocrine Signaling

47.8K
Autocrine signaling is one of the many signaling mechanisms that function inside multicellular organisms to carry out intercellular communication. In this type of signaling mechanism, the same cell that secretes an extracellular signaling molecule also expresses the receptors to bind and respond to that signaling molecule.
Autocrine Signaling in Macrophages
Under normal physiological conditions, autocrine signaling is essential for maintaining homeostasis. This process is well characterized in...
47.8K
Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

2.6K
Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
2.6K
Paracrine Signaling01:21

Paracrine Signaling

54.8K
Paracrine signaling allows cells to communicate with their immediate neighbors via secretion of signaling molecules. Such a signal can only trigger a response in nearby target cells because the signal molecules degrade quickly or are inactivated if not taken up. Prominent examples of paracrine signaling include nitric oxide signaling in blood vessels, synaptic signaling of neurons, the blood clotting system, tissue repair/wound healing, and local allergic skin reactions. Nitric oxide as a...
54.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CD44 facilitates adhesive interactions in airineme-mediated intercellular signaling.

Frontiers in cell and developmental biology·2025
Same author

Cytoneme-mediated intercellular signaling in keratinocytes is essential for epidermal remodeling in zebrafish.

eLife·2025
Same author

CD44 facilitates adhesive interactions in airineme-mediated intercellular signaling.

bioRxiv : the preprint server for biology·2024
Same author

Cytoneme-mediated intercellular signaling in keratinocytes is essential for epidermal remodeling in zebrafish.

bioRxiv : the preprint server for biology·2023
Same author

Q&A with Dae Seok Eom.

Cell reports·2023
Same author

A macrophage subpopulation promotes airineme-mediated intercellular communication in a matrix metalloproteinase-9 dependent manner.

Cell reports·2023

Related Experiment Video

Updated: Jun 14, 2025

Single-cell Microinjection for Cell Communication Analysis
09:59

Single-cell Microinjection for Cell Communication Analysis

Published on: February 26, 2017

11.3K

Airineme-Mediated Intercellular Communication.

Dae Seok Eom1

  • 1Department of Developmental and Cell Biology, University of California, Irvine, CA, USA. dseom@uci.edu.

Results and Problems in Cell Differentiation
|September 6, 2024
PubMed
Summary
This summary is machine-generated.

Researchers explored airinemes, novel cellular protrusions in zebrafish skin, revealing their role in long-range intercellular communication. Understanding these structures is key to deciphering complex biological signaling pathways.

Keywords:
AirinemesCellular protrusionsCytonemesIntercellular communicationMacrophagesMelanophoresMetaphocytesNotchPigment cellsXanthophoresZebrafish

More Related Videos

Mechanical Stimulation-induced Calcium Wave Propagation in Cell Monolayers: The Example of Bovine Corneal Endothelial Cells
10:46

Mechanical Stimulation-induced Calcium Wave Propagation in Cell Monolayers: The Example of Bovine Corneal Endothelial Cells

Published on: July 16, 2013

16.2K
Ex Vivo Calcium Imaging for Visualizing Brain Responses to Endocrine Signaling in Drosophila
06:49

Ex Vivo Calcium Imaging for Visualizing Brain Responses to Endocrine Signaling in Drosophila

Published on: June 2, 2018

9.2K

Related Experiment Videos

Last Updated: Jun 14, 2025

Single-cell Microinjection for Cell Communication Analysis
09:59

Single-cell Microinjection for Cell Communication Analysis

Published on: February 26, 2017

11.3K
Mechanical Stimulation-induced Calcium Wave Propagation in Cell Monolayers: The Example of Bovine Corneal Endothelial Cells
10:46

Mechanical Stimulation-induced Calcium Wave Propagation in Cell Monolayers: The Example of Bovine Corneal Endothelial Cells

Published on: July 16, 2013

16.2K
Ex Vivo Calcium Imaging for Visualizing Brain Responses to Endocrine Signaling in Drosophila
06:49

Ex Vivo Calcium Imaging for Visualizing Brain Responses to Endocrine Signaling in Drosophila

Published on: June 2, 2018

9.2K

Area of Science:

  • Cell Biology
  • Developmental Biology
  • Signaling Pathways

Background:

  • Intercellular communication is vital for multicellular organisms, with disruptions causing developmental and homeostatic issues.
  • Recent research has uncovered new signaling methods beyond established ones.
  • Cellular protrusions mediating long-range communication represent a significant advance in understanding cell signaling.

Purpose of the Study:

  • To explore airinemes, a specific type of cellular protrusion found in zebrafish skin.
  • To elucidate the signaling roles and underlying mechanisms of airinemes.

Main Methods:

  • Microscopy techniques to visualize cellular protrusions.
  • Genetic and molecular analyses to identify signaling components.
  • Functional assays to determine the roles of airinemes in intercellular communication.

Main Results:

  • Identification and characterization of airinemes in zebrafish skin.
  • Demonstration of airinemes' involvement in long-range intercellular signaling.
  • Elucidation of cellular and molecular mechanisms governing airineme function.

Conclusions:

  • Airinemes represent a novel mode of intercellular communication.
  • Understanding airinemes provides insights into developmental and homeostatic processes.
  • Further research into airinemes can inform strategies for addressing human health concerns related to cell signaling.