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Updated: Jun 14, 2025
08:49
A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
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Updates in the Management of Advanced Nonmelanoma Skin Cancer
Flora Yan1, Cecelia E Schmalbach1
1Department of Otolaryngology-Head & Neck Surgery, Lewis Katz School of Medicine at Temple Hospital, Philadelphia, PA, USA.
Surgical Oncology Clinics of North America
|September 7, 2024
Summary
New treatments for nonmelanoma skin cancers like basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC) are available. These include advanced therapies such as hedgehog inhibitors and immune checkpoint inhibitors for challenging cases.
Area of Science:
- Oncology
- Dermatology
Background:
- Basal cell carcinoma (BCC), cutaneous squamous cell carcinoma (cSCC), and Merkel cell carcinoma (MCC) are common nonmelanoma skin cancers.
- Significant advancements in treatment strategies have emerged for these malignancies.
Purpose of the Study:
- To summarize current treatment advances for BCC, cSCC, and MCC.
- To highlight indications for novel therapeutic modalities.
Main Methods:
- Review of recent therapeutic developments in nonmelanoma skin cancers.
- Identification of patient populations eligible for advanced treatments.
Main Results:
- Sentinel lymph node biopsy is recommended for locally advanced, node-negative cSCC and MCC.
- Hedgehog inhibitors are effective for BCC patients refractory to traditional treatments.
- Immune checkpoint inhibitors (e.g., cemiplimab, pembrolizumab, avelumab, retifanlimab-dlwr) offer options for advanced or refractory BCC, cSCC, and MCC.
Conclusions:
- Modern treatment algorithms for nonmelanoma skin cancers incorporate advanced systemic therapies.
- Targeted therapies and immunotherapies represent significant progress in managing advanced BCC, cSCC, and MCC.
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