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Updated: Jun 13, 2025

Assessment of Vascular Function in Patients With Chronic Kidney Disease
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Matrix Gla Protein and Nitric Oxide Synthase-3 Genetic Variants in Chronic Kidney Disease and Their Relation with

G Priyadarshini1, Sreejith Parameswaran2, Jayaprakash Sahoo3

  • 1Department of Biochemistry Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

International Journal of Nephrology
|September 9, 2024
PubMed

Insights

Genetic variants in the matrix Gla protein (MGP) and nitric oxide synthase-3 (NOS3) genes increase the risk of chronic kidney disease (CKD) and associated cardiovascular disease in South Indian Tamils.

Area of Science:

  • Genetics
  • Nephrology
  • Cardiology

Background:

  • Chronic kidney disease (CKD) is characterized by progressive loss of kidney function.
  • CKD significantly elevates the risk of cardiovascular events, a link not fully understood.
  • Endothelial dysfunction is a key factor in the CKD-cardiovascular disease association.

Purpose of the Study:

  • To investigate the association between genetic variants in the MGP and NOS3 genes and the risk of CKD.
  • To examine the influence of these genetic variants on cardiovascular comorbidity in CKD patients.
  • To explore the relationship between these genetic variants, nitric oxide (NO) levels, and endothelial function.

Main Methods:

  • Genotyping of MGP (rs1800801, rs1800802, rs4236) and NOS3 (rs1799983, rs2070744) polymorphisms in 185 CKD patients and 185 controls.
  • Measurement of circulating nitric oxide (NO) levels using ELISA.
  • Assessment of brachial artery flow-mediated dilatation (FMD) via ultrasound to evaluate endothelial function.

Main Results:

  • Specific genotypes of NOS3 (rs2070744) and MGP polymorphisms were significantly associated with an increased risk of CKD.
  • Lower NO levels were observed in CKD patients compared to controls.
  • Certain MGP and NOS3 genotypes correlated with decreased FMD, indicating endothelial dysfunction.

Conclusions:

  • Genetic variations in MGP and NOS3 genes contribute to the risk of developing CKD.
  • These genetic factors also appear to enhance the risk of cardiovascular complications in individuals with CKD.
  • The study highlights the role of genetic predisposition in the complex interplay between CKD and cardiovascular disease in the South Indian Tamil population.
Abstract

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