Facile construction of 2-pyrones under carbene catalysis
Miao Yu1, Jie Huang2, Haibin Zhu2
1Engineering Research Center for Medicine, Ministry of Education, Harbin University of Commerce Harbin 150076 China liuyj691@nenu.edu.cn jyb@hrbcu.edu.cn.
Abstract:
2-Pyrones are valuable structural motifs in organic chemistry, found in numerous natural products and pharmaceuticals. The synthesis of these heterocycles has been significantly advanced by the application of N-Heterocyclic Carbene (NHC) catalysis. This review examines the recent advancements in NHC-catalyzed synthesis of 2-pyrones, highlighting key methodologies, mechanisms, and synthetic applications. NHC catalysis has revolutionized the synthesis of 2-pyrones, providing efficient, selective, and versatile methods for constructing these valuable heterocycles.
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