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Inverted U-Shaped relationship Between Systemic Immune-Inflammation Index and Pulmonary Function: A Large
Qian Yuan1, Long-Wu Xiao1, Yao Zhang1
1Department of Thoracic Surgery, Nan Jing Gaochun PEople's Hospital (The Gaochun Affiliated Hospital of Jiang Su University), Nanjing, Jiangsu, 210000, People's Republic of China.
International Journal of Chronic Obstructive Pulmonary Disease
|September 9, 2024
Summary
The Systemic Immune-inflammation Index (SII) is linked to reduced lung function. This study identified a threshold where elevated SII indicates declining lung function, suggesting its potential as a predictive marker.
Area of Science:
- Pulmonology
- Immunology
- Biomarker Research
Background:
- The Systemic Immune-inflammation Index (SII) is a novel marker reflecting systemic inflammation.
- Inflammation is recognized as a contributing factor to impaired lung function.
- Understanding the relationship between SII and lung function is crucial for identifying predictive markers of respiratory health.
Purpose of the Study:
- To investigate the association between the Systemic Immune-inflammation Index (SII) and lung function.
- To explore the potential of SII as a predictor of lung function decline.
- To identify threshold values of SII associated with significant changes in pulmonary function.
Main Methods:
- Cross-sectional analysis of NHANES data (2007-2012) involving 10,125 participants.
- Multiple linear regression models were employed to assess the relationship between SII and pulmonary function indices.
- Sensitivity, subgroup, and interaction analyses were performed to ensure robustness; nonlinear relationships were examined using smooth curves and threshold effect analysis.
Main Results:
- Elevated Log2-SII levels were significantly associated with decreased FVC, FEV1, FEV1%, FEV1/FVC, and PEF after covariate adjustment.
- The negative correlation between Log2-SII and pulmonary function indices was consistent across trend and stratified analyses.
- Inverted U-shaped relationships were observed between Log2-SII and FVC, FEV1, FEV1%, and PEF, with specific nonlinear thresholds identified; a negative linear correlation was found for FEV1/FVC.
Conclusions:
- A significant correlation exists between the Systemic Immune-inflammation Index (SII) and key pulmonary function indicators.
- Specific SII thresholds were identified beyond which lung function significantly declines.
- SII shows promise as a serological indicator for predicting lung function decline, warranting further prospective research to establish causality.
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