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Related Experiment Video

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Deep Brain Stimulation with Simultaneous fMRI in Rodents
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Neuromodulation in Small Animal fMRI.

Li-Ming Hsu1,2,3, Yen-Yu Ian Shih1,2,4

  • 1Center for Animal Magnetic Resonance Imaging, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

Journal of Magnetic Resonance Imaging : JMRI
|September 16, 2024
PubMed
Summary

Combining functional magnetic resonance imaging (fMRI) with neuromodulation techniques in animal models reveals cell-type specific brain activity and network dynamics, advancing neuroscience research.

Keywords:
chemogeneticsdeep brain stimulationfMRIoptogenetics

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Area of Science:

  • Neuroscience
  • Brain Imaging
  • Animal Models

Background:

  • Investigating causal links between brain activity and network function is challenging in humans.
  • Small animal models offer a unique platform for such research.

Purpose of the Study:

  • To review neuromodulation techniques (electrical deep brain stimulation, optogenetics, chemogenetics) used with fMRI in rodents.
  • To demonstrate how this multimodal approach elucidates brain signaling, neurovascular coupling, and behavior.

Main Methods:

  • Review of historical development and application of neuromodulation techniques with fMRI in rodents.
  • Discussion of methodological considerations for combined experiments.
  • Presentation of rodent-based case studies.

Main Results:

  • Highlights cell-type and circuit-specific modulation of brain-wide activity patterns and behavioral correlates.
  • Demonstrates insights into neurovascular coupling and neural basis of brain network functions.
  • Shows integration bridges mesoscopic and macroscopic scales of neuroscience.

Conclusions:

  • fMRI combined with neuromodulation provides crucial insights into brain dynamics at multiple scales.
  • This integration advances understanding of brain function in health and disease.
  • Facilitates exploration of novel therapeutic strategies for network-mediated behaviors.