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[Association of Gut and Oral Microbiota with Cerebral Aneurysms]

Masatoshi Takagaki1, Shuhei Kawabata, Haruhiko Kishima

  • 1Department of Neurosurgery, Osaka University Graduate School of Medicine.

No Shinkei Geka. Neurological Surgery
|September 17, 2024
PubMed

Insights

The oral and gut microbiomes are linked to cerebral aneurysms and inflammation. Targeting the microbiome may offer new treatments for brain injury after subarachnoid hemorrhage.

Area of Science:

  • Microbiology
  • Neurology
  • Immunology

Background:

  • The microbiome's association with various diseases is increasingly recognized.
  • The oral and gut microbiomes are implicated in cerebral aneurysms and systemic inflammation.
  • Chronic inflammation is a key factor in cerebral aneurysm pathogenesis and rupture.

Purpose of the Study:

  • To explore the role of the microbiome in cerebral aneurysms.
  • To investigate the microbiome's involvement in inflammation related to cerebral aneurysms.
  • To highlight the potential of microbiome-targeted therapies for neurological conditions.

Main Methods:

  • Literature review on microbiome-disease associations.
  • Analysis of studies linking oral and gut microbiomes to cerebral aneurysms.
  • Examination of the role of inflammation in aneurysm development and rupture.

Main Results:

  • The oral and gut microbiomes are associated with cerebral aneurysms.
  • Microbiome-mediated inflammation plays a role in cerebral aneurysm pathogenesis.
  • The gut microbiome influences acute brain injury following subarachnoid hemorrhage.

Conclusions:

  • The microbiome is a significant factor in cerebral aneurysm development and rupture.
  • Microbiome-gut-brain axis interactions are crucial in neurological diseases.
  • Further research into microbiome-targeted treatments for cerebral aneurysms is warranted.

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