Hypoparathyroidism and assisted reproductive technology: considerations while undergoing ovarian hyperstimulation.

Area of Science:

• Endocrinology
• Reproductive Medicine
• Calcium Homeostasis

Background:

• Hypoparathyroidism (hypoPTH) necessitates strict calcium level management to avoid hypocalcemia and hypercalcemia.
• Pregnancy and lactation affect calcium balance, but the impact of ovarian stimulation on calcium homeostasis in hypoPTH is unknown.
• Growing use of assisted reproductive technology (ART) highlights the need for understanding its implications for hypoPTH patients.

Purpose of the Study:

• To explore the impact of controlled ovarian stimulation on calcium homeostasis in patients with hypoparathyroidism.
• To provide guidance for fertility care in patients with hypoPTH undergoing ART.

Main Methods:

• Literature review on calcium homeostasis during pregnancy and lactation.
• Presentation of the first case study of a patient with hypoparathyroidism undergoing ART.

Main Results:

• No existing literature addresses calcium homeostasis during controlled ovarian stimulation in hypoparathyroidism.
• Physiological changes during pregnancy affecting calcium homeostasis are discussed.
• A case presentation of a hypoparathyroidism patient undergoing ART is included.

Conclusions:

• This article offers initial insights and recommendations for fertility care in hypoparathyroidism patients.
• It addresses a critical knowledge gap concerning ART and hypoparathyroidism management.