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Disturbed Atrial Conduction in Patients with Duchenne Muscular Dystrophy

Özlem Turan1, Abdullah Kocabaş1

  • 1Department of Pediatric Cardiology, Antalya Training and Research Hospital, University of Health Sciences, Antalya, Türkiye.

Anatolian Journal of Cardiology
|September 18, 2024
PubMed

Insights

Duchenne muscular dystrophy (DMD) in children impairs heart function, causing systolic and diastolic issues, and abnormal atrial conduction. This increases their risk for atrial arrhythmias.

Area of Science:

  • Cardiology
  • Pediatric Cardiology
  • Electrophysiology

Background:

  • Duchenne muscular dystrophy (DMD) is linked to early-onset cardiomyopathy with hemodynamic and conduction abnormalities.
  • Subtle symptoms often mask the progression of DMD-related cardiac issues.

Purpose of the Study:

  • To investigate cardiac function and atrial electromechanical delay in children with DMD.
  • To compare electrocardiogram (ECG) and echocardiographic parameters between DMD patients and healthy controls.

Main Methods:

  • Compared ECG, conventional echocardiography, and tissue Doppler imaging (TDI) in 55 DMD patients and 54 controls.
  • Analyzed mitral, septal, and tricuspid segments using TDI.
  • Assessed atrial electromechanical delay, P-wave dispersion (PWD), and interatrial conduction delays.

Main Results:

  • DMD patients exhibited higher heart rates, prolonged QTc intervals, and increased PWD compared to controls.
  • Left ventricular ejection fraction (EF) was reduced, with impaired systolic (TAPSE, MAPSE) and diastolic (mitral-E/A, E'/A') function in DMD patients.
  • Patients with DMD showed significantly longer atrial electromechanical delay and interatrial conduction delays, with EF negatively correlated to atrial conduction times.

Conclusions:

  • Children with DMD demonstrate impaired ventricular systolic and diastolic function, alongside compromised atrial conduction.
  • Disturbed atrial conduction in DMD patients suggests an elevated risk for developing atrial arrhythmias.
Abstract

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