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A disposable fiber-optic plasmonic sensor for chemical sensing.
Tao Han1, Cheng Zhang2, Hui Yu2
1College of Life Science, Qingdao University, Qingdao, Shandong, 266071, China.
Analytical Biochemistry
|September 18, 2024
Summary
This study introduces a novel fiber-optic plasmonic sensor using gold nanoparticles for sensitive detection of lead ions and E. coli. The cost-effective and disposable design enables practical point-of-care testing applications.
Area of Science:
- Nanotechnology
- Biomedical Engineering
- Analytical Chemistry
Background:
- Conventional sensors are bulky and complex.
- High-sensitivity plasmonic sensors require intricate nanostructure fabrication.
- There is a need for cost-effective, user-friendly sensing platforms.
Purpose of the Study:
- To develop a simple, cost-effective fiber-optic plasmonic sensor.
- To demonstrate its application in detecting heavy metals and bacteria.
- To enable practical point-of-care testing.
Main Methods:
- Utilized chemically absorbed gold nanoparticles on optical fibers.
- Functionalized nanoparticles with aptamers/antibodies for specific binding.
- Employed two detection modes: resonance wavelength shift and absorption peak amplitude measurement.
Main Results:
- Detected lead ions (Pb2+) with a limit of detection of 0.097 nM.
- Detected E. coli in urinary tract infection samples with a dynamic range of 10^3 to 10^8 CFU/mL.
- Demonstrated high linearity and sensitivity in both detection modes.
Conclusions:
- The developed sensor offers high sensitivity and simple fabrication.
- The replaceable configuration enhances usability and reduces cost.
- This approach holds potential for point-of-care diagnostics using fiber-optic plasmonic sensors.
