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Updated: Jun 12, 2025
07:15
Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
11.3K
Epidemiological associations between periodontitis and cancer
Jon Higham1, Frank A Scannapieco2
1Department of Oral Medicine, Birmingham Dental Hospital and School of Dentistry, Birmingham, UK.
Periodontology 2000
|September 20, 2024
Summary
Periodontitis, an oral infection, is linked to various cancers. While evidence suggests an association, more research is needed to confirm if gum disease directly causes cancer.
Area of Science:
- Oral Health and Oncology
- Epidemiology of Chronic Diseases
Background:
- Periodontitis is a chronic inflammatory condition affecting the gums and supporting bone.
- Emerging research suggests a potential link between periodontitis and increased cancer risk.
Purpose of the Study:
- To review current epidemiological evidence on the association between periodontitis and various human cancers.
- To synthesize findings from cohort and case-control studies regarding this association.
Main Methods:
- A narrative review approach was employed.
- A comprehensive PubMed search was conducted using keywords: periodontal disease, periodontitis, cancer, and malignancy.
- Relevant articles were identified and analyzed.
Main Results:
- Epidemiological evidence supports an association between periodontal disease and multiple cancers, including oral, stomach, colorectal, lung, pancreatic, prostate, hematological, liver, breast, and ovarian cancers.
- The majority of evidence comes from observational studies (cohort and case-control).
Conclusions:
- A considerable body of epidemiological evidence suggests an association between periodontal disease and cancer.
- The association may be circumstantial due to limited evidence from treatment trials validating the role of periodontitis in cancer initiation and development.
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