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Updated: Jun 12, 2025
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Published on: March 21, 2021
Body Composition, Sarcopenia, and Serum Myokines in Acromegaly: A Narrative Review
Arthur Costa Inojosa1,2, Ana Vitória Hirt Ribeiro1,2, Thaís Florêncio Araújo1,2
1Division of Endocrinology, Agamenon Magalhães Hospital, University of Pernambuco Medical School, Recife, Brazil.
Abstract:
Patients with active acromegaly have a higher percentage of lean body mass, a lower percentage of fat body mass, and an increase in their extracellular water compartment compared to healthy individuals. However, muscle function appears to be compromised in patients with acromegaly, with some experiencing worsened physical performance and sarcopenia. Myokine alterations, insulin resistance, dysregulation of protein metabolism, muscle oxidative stress, neuromuscular junction impairment, and increased ectopic intramuscular fat deposits may play roles in muscle dysfunction in patients with acromegaly.
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