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Published on: February 7, 2018
Effects of Psychogenic Stress Frequency during the Growth Stage on Oxidative Stress, Organ and Bone Development
Sangun Lee1,2, Maho Tairabune2, Yuka Nakamura2
1Aomori University of Health and Welfare Graduate School of Health Sciences, Aomori, Japan.
Insights
Frequent psychogenic stress (PS) during development increases oxidative stress and impairs organ and bone growth. High-frequency PS exposure negatively impacts growth and development, with oxidative stress playing a key role.
Area of Science:
- Physiology
- Developmental Biology
- Stress Research
Background:
- Investigating the impact of psychogenic stress (PS) on physiological development is crucial for understanding growth-related processes.
- Oxidative stress is a key factor implicated in various physiological disruptions during development.
Purpose of the Study:
- To determine the effects of varying psychogenic stress (PS) frequencies on oxidative stress levels.
- To assess the impact of PS on organ development and growth parameters.
- To elucidate fundamental insights into developmental processes under stress conditions.
Main Methods:
- Four-week-old male Wistar rats were utilized, divided into control and three PS groups.
- Psychogenic stress was induced daily for 4 weeks using restraint and water immersion for 3 hours.
- PS frequencies were systematically varied across experimental groups.
Main Results:
- A dose-dependent increase in oxidative stress was observed with rising PS frequency.
- Organ weights (excluding adrenal glands) significantly decreased with increasing PS frequency, indicating growth suppression.
- Bone morphology, weight, and length were negatively impacted by higher PS frequencies.
Conclusions:
- High-frequency psychogenic stress during developmental growth adversely affects oxidative stress, organ development, and bone growth.
- Elevated oxidative stress resulting from excessive PS poses detrimental effects on overall growth and skeletal development.
Background:
This study aimed to examine the effects of psychogenic stress (PS) frequency on oxidative stress and organ development during growth and to gain fundamental insights into developmental processes during this period.
Methods:
Four-week-old male Wistar rats were randomly assigned to a control and three PS groups according to PS frequencies. PS was induced using restraint and water immersion techniques once daily for 3 hr at a time for a period of 4 weeks.
Results:
Oxidative stress increased with increasing PS frequency. The weights of organs other than the adrenal glands significantly decreased with increasing PS frequency, indicating growth suppression. Furthermore, bone morphology, weight, and length significantly decreased with increasing PS frequency.
Conclusions:
High-frequency PS exposure during developmental growth significantly negatively affects oxidative stress and organ and bone development. In particular, increased oxidative stress due to excessive PS has detrimental effects on organ and bone growth.
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