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Updated: Jul 22, 2026
07:07
Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice
Published on: January 12, 2017
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Effect of four direct pulp capping agents on human dental pulp tissue
Prerna Goel1, Navneet Kukreja1, Sushruth Nayak2
1Department of Conservative and Endodontics, M.M College of Dental Sciences and Research, Mm (Deemed to be University), Mullana, Ambala, India.
Bioinformation
|September 23, 2024
Summary
Direct pulp capping (DPC) using Tristrontium aluminate, ProRoot MTA, Biodentine, and TheraCal LC successfully induced dentine bridge formation and maintained pulp vitality. The new Tristrontium aluminate shows promise for future vital pulp therapy applications.
Area of Science:
- Dentistry
- Biomaterials Science
- Regenerative Medicine
Background:
- Direct pulp capping (DPC) is crucial for vital pulp therapy, aiming to preserve tooth vitality after pulp exposure.
- Material selection is a key determinant of success in DPC procedures.
- Evaluating novel biomaterials alongside established ones is essential for advancing dental treatments.
Purpose of the Study:
- To compare the efficacy of Tristrontium aluminate against ProRoot MTA, Biodentine, and TheraCal LC in direct pulp capping.
- To assess the dentine bridge formation and pulpal response to these materials.
- To investigate the potential of Tristrontium aluminate as a DPC material.
Main Methods:
- 40 premolars undergoing orthodontic extraction were used for iatrogenic direct pulp capping.
- Teeth were divided into four groups, each receiving one of the tested materials: Tristrontium aluminate, ProRoot MTA, Biodentine, or TheraCal LC.
- After 90 days, teeth were extracted and analyzed using CBCT and histopathological examination for dentine bridge formation and pulpal healing.
Main Results:
- All tested materials, including Tristrontium aluminate, successfully induced the formation of a dentine bridge.
- Pulp vitality was maintained in all experimental groups.
- Histopathological and CBCT analyses confirmed the biocompatibility and reparative potential of the materials.
Conclusions:
- Tristrontium aluminate, ProRoot MTA, Biodentine, and TheraCal LC are all effective in promoting dentine repair and maintaining pulp vitality in direct pulp capping.
- Tristrontium aluminate demonstrates significant potential for future applications in vital pulp therapy.
- The study highlights the importance of material choice in achieving successful outcomes in direct pulp capping.
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