Dynamic functional connectivity in verbal cognitive control and word reading
Kazuki Sakakura1, Matthew Brennan2, Masaki Sonoda3
1Department of Pediatrics, Children's Hospital of Michigan, Detroit Medical Center, Wayne State University, Detroit, MI 48201, United States; Department of Neurosurgery, Rush University Medical Center, Chicago, IL 60612, United States; Department of Neurosurgery, University of Tsukuba, Tsukuba 3058575, Japan.
Automatic word reading relies on occipital-temporal white matter tracts, while verbal cognitive control, like the Stroop task, engages frontal pathways. This study maps these distinct neural dynamics.
Area of Science:
- Neuroscience
- Cognitive Neuroscience
- Neuroimaging
Background:
- Cognitive control involves suppressing automatic responses and initiating appropriate actions.
- The Stroop color naming task is a key paradigm for studying verbal cognitive control.
- Previous studies highlight prefrontal and premotor cortex involvement in the Stroop task versus reading.
Purpose of the Study:
- To create a dynamic atlas of task-preferential white matter functional connectivity modulations.
- To differentiate the neural pathways underlying automatic word reading and verbal cognitive control.
Main Methods:
- Intracranial EEG recordings during word-reading and Stroop tasks in patients.
- Quantification of task-related high-gamma amplitude modulations at 547 electrode sites.
- Mixed model analysis to identify task-differential amplitude regions and timeframes.
- Dynamic tractography visualization of white matter pathways with enhanced functional connectivity.
Main Results:
- Word reading showed enhanced connectivity in left occipital-temporal white matter tracts (350-600 ms before response).
- Stroop task showed enhanced connectivity in left middle frontal-precentral pathways.
- Distinct white matter pathway engagement was identified for automatic reading versus cognitive control.
Conclusions:
- Automatic word reading primarily utilizes left occipital-temporal cortices and associated white matter.
- Verbal cognitive control predominantly involves left middle frontal and precentral gyri and their connected pathways.
- Dynamic tractography atlases offer novel insights into the unique neural dynamics of reading and cognitive control.
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