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Updated: Jun 12, 2025

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Closure of a Patent Foramen Ovale PFO: An Intervention Sequence
Published on: December 23, 2022
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Patent Foramen Ovale Embryology, Anatomy, and Physiology
Adeba Mohammad1, HuuTam Truong2, Islam Abudayyeh3
1Cardiology Department, Loma Linda University Health, 1234 Anderson Street, Loma Linda, CA 92354, USA.
Cardiology Clinics
|September 25, 2024
Summary
Patent foramen ovale (PFO) is common but can cause stroke. Safe closure requires understanding atrial anatomy and right-to-left heart flows using echocardiography before the procedure.
Area of Science:
- Cardiology
- Medical Imaging
Background:
- Patent foramen ovale (PFO) is a frequent condition in the general population.
- PFO can precipitate serious health issues, including stroke and platypnea-orthodeoxia syndrome.
Purpose of the Study:
- To emphasize the critical role of interatrial septal anatomy understanding for safe transcatheter PFO closure.
- To highlight the importance of imaging in assessing PFO and guiding closure procedures.
Main Methods:
- Utilizing transesophageal echocardiography (TEE) and intracardiac echocardiography (ICE) for imaging.
- Detailed investigation of right heart to left heart flows.
- Assessment of interatrial septal anatomy.
Main Results:
- Accurate anatomical assessment and flow dynamics are crucial for successful PFO closure.
- TEE and ICE provide essential imaging for evaluating PFO and associated risks.
- Pre-procedural imaging guides the decision-making process for transcatheter closure.
Conclusions:
- A comprehensive understanding of atrial anatomy and hemodynamics is paramount for safe and effective transcatheter PFO closure.
- Echocardiography is indispensable for pre-procedural evaluation of PFO.
- Thorough pre-closure assessment minimizes procedural risks and optimizes patient outcomes.
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