Related Experiment Video

Updated: Jul 6, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

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Migraine Headache and Patent Foramen Ovale: Observational Studies, the Randomized Clinical Trials, and the GORE

Robert J Sommer1, Barbara T Robbins1

  • 1Department of Medicine, Division of Interventional Cardiology, Columbia University Medical Center, 161 Fort Washington Avenue, Room 624, New York, NY 10032, USA.

Cardiology Clinics
|September 25, 2024
PubMed

Insights

Patent foramen ovale (PFO) closure may help reduce migraine symptoms, particularly in patients with platelet activation. The GORE RELIEF study is investigating this link further.

Area of Science:

  • Neurology
  • Cardiology
  • Clinical Trials

Background:

  • The exact causes of migraine pathophysiology are not fully understood.
  • Patent foramen ovale (PFO) closure, while not initially for migraine treatment, has shown potential symptom reduction in some patients.
  • Previous small trials have yielded inconclusive results regarding PFO closure for migraine prevention.

Purpose of the Study:

  • To investigate the efficacy of PFO closure in reducing migraine symptoms.
  • To explore a potential platelet-mediated mechanism linking PFO and migraines.
  • To optimize patient selection for PFO closure trials using thienopyridine responsiveness.

Main Methods:

  • The GORE RELIEF Clinical Study is a randomized, blinded, placebo- and sham-controlled trial.
  • Patient selection is optimized by using thienopyridine responsiveness as an inclusion criterion.
  • The study aims to provide robust data on PFO closure for migraine treatment.

Main Results:

  • The study is currently enrolling patients.
  • Results are pending, but the design aims to clarify the role of PFO in migraine.
  • Investigating platelet-mediated mechanisms is a key component.

Conclusions:

  • Further research is needed to establish PFO closure as a viable migraine treatment.
  • Optimized patient selection may be crucial for future trial success.
  • Understanding the underlying mechanisms is essential for developing effective migraine therapies.
Keywords:
Migraine headacheP2Y12 inhibitionPatent foramen ovalePlateletsTrials

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