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Updated: Jun 12, 2025
10:52
Closure of a Patent Foramen Ovale PFO: An Intervention Sequence
Published on: December 23, 2022
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Patent Foramen Ovale and Hypoxemia.
Ashley Nguyen1, Elaine Nguyen2, Preetham Kumar3
1Department of Medicine, Cleveland Clinic Florida, 2950 Cleveland Clinic Boulevard, Weston, FL 33331, USA.
Cardiology Clinics
|September 25, 2024
Summary
A patent foramen ovale (PFO) is linked to stroke and migraines, but also less common conditions like platypnea-orthodeoxia syndrome and sleep apnea. This review explores these PFO-associated conditions.
Area of Science:
- Cardiology
- Pulmonology
- Neurology
Background:
- A patent foramen ovale (PFO) is an atrial septal defect present in adults.
- While commonly associated with cryptogenic stroke and migraine with aura, PFO has other clinical implications.
Purpose of the Study:
- To discuss and summarize literature on less common conditions associated with PFO.
- To explore the link between PFO and platypnea-orthodeoxia syndrome, obstructive sleep apnea, and COPD with disproportionate hypoxemia.
Main Methods:
- Literature review of studies examining PFO and associated conditions.
- Synthesis of findings related to clinical manifestations and pathophysiology.
Main Results:
- PFO is implicated in platypnea-orthodeoxia syndrome, characterized by respiratory distress when upright.
- PFO is also associated with obstructive sleep apnea and hypoxemia in COPD patients.
Conclusions:
- PFO presents with a spectrum of clinical manifestations beyond stroke and migraine.
- Understanding these associations is crucial for comprehensive patient management.
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