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Opioid receptors, including the mu (μ, MOR), delta (δ, DOR), and kappa (κ, KOR) types, belong to the rhodopsin family of G protein-coupled receptors. These receptors are located throughout the central and peripheral nervous systems and in non-neuronal tissues such as macrophages and astrocytes. Opioid receptor ligands can be categorized into agonists or antagonists. Highly selective agonists include [d-Ala2, MePhe4, Gly(ol)5]-enkephalin or DAMGO for MOR, [D-Pen2,...
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Macrocyclic receptors for anion recognition.

Farhad Ali Mohammed1,2, Tangxin Xiao3, Leyong Wang3,4

  • 1Department of Chemistry, Maynooth University, National University of Ireland, Maynooth, Co, Kildare, Ireland. robert.elmes@mu.ie.

Chemical Communications (Cambridge, England)
|September 26, 2024
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Summary
This summary is machine-generated.

Macrocyclic receptors are key tools for detecting anions in chemistry and biology. This review highlights recent progress in designing and using these versatile molecules for anion recognition.

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Area of Science:

  • Supramolecular Chemistry
  • Molecular Recognition
  • Chemical Sensing

Background:

  • Macrocyclic receptors are increasingly important in molecular recognition.
  • Anion sensing is a critical area in chemical and biological sciences.
  • Traditional methods for anion recognition face limitations.

Purpose of the Study:

  • To review recent advances in macrocyclic receptors for anion recognition.
  • To highlight the design, synthesis, and applications of these receptors.
  • To emphasize the structural advantages of macrocycles for anion binding.

Main Methods:

  • Literature review of recent research on macrocyclic anion receptors.
  • Analysis of structural features contributing to anion binding.
  • Survey of diverse applications in chemical and biological sciences.

Main Results:

  • Macrocyclic receptors offer efficient and selective anion recognition.
  • Unique structural features like pre-organized binding sites enhance binding.
  • Applications span various fields, including sensing and catalysis.

Conclusions:

  • Macrocyclic receptors are powerful tools for anion recognition and sensing.
  • Continued innovation in their design promises broader applications.
  • Their well-defined structures are crucial for their effectiveness.