Effectiveness of cellulite treatment with combined enzymatic therapy

Cellulite, also known as edematous fibrosclerotic panniculopathy (EFP), affects up to 90% of women and has a significant aesthetic impact. EFP is a multifactorial condition characterized by local circulatory changes, increased adipose tissue thickness, and a fibrotic response involving thick collagen bundles and septa, driven by local hypoxia. Although numerous treatments exist, their effects are typically temporary. This study evaluates the outcomes of four patients with EFP treated using a combined recombinant enzymatic therapy consisting of a lyase, lipase, and collagenase.

A standardized protocol involving injections of a combined enzyme solution (pbserum Medium™) was administered to the lower limbs in three separate sessions. Pre- and post-treatment photographs were collected for comparative analysis.

All four patients showed improvements in skin appearance and fibrosis, with no systemic or local adverse events reported.

We propose that a treatment strategy targeting the edematous, adipose, and fibrotic components of EFP may offer an economical and pathogenic-based approach for managing this condition in affected women.