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Intracellular C1q - an unexpected player in neuronal proteostasis.

Erin E West1, Claudia Kemper1

  • 1Complement and Inflammation Research Section, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.

Trends in Immunology
|September 26, 2024
PubMed
Summary

Microglia release complement component C1q, which binds to neuronal ribosomes in aging brains. This unexpected interaction impairs protein translation and hinders the extinction of fear responses in mice.

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