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Inositol Hexaphosphate in Bone Health and Disease.

Yuji Yoshiko1, Ivana Vucenik2

  • 1Pi Skovy, 1-15-31-9, Mukainadahonmachi, Minami-ku, Hiroshima 734-0062, Japan.

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Summary
This summary is machine-generated.

Dietary myo-inositol hexaphosphate (IP6) can inhibit pathological calcification but may also affect bone health. Further research is needed to understand IP6

Keywords:
bone formationbone resorptionhumanslaboratory animalsmyo-inositol hexaphosphate

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Area of Science:

  • Biochemistry and Molecular Biology
  • Nutritional Science
  • Bone Physiology

Background:

  • Dietary myo-inositol hexaphosphate (IP6), also known as phytic acid, is a plant-derived compound historically considered an antinutrient due to its mineral-chelating properties.
  • Emerging research highlights IP6's potential beneficial effects, including anti-inflammatory, antibacterial, and anticancer activities, and its presence in mammalian cells.
  • IP6's ability to inhibit hydroxy-apatite and calcium oxalate crystal growth suggests therapeutic potential for pathological calcification.

Purpose of the Study:

  • To investigate the dual role of myo-inositol hexaphosphate (IP6) in both inhibiting pathological calcification and potentially influencing physiological bone mineralization.
  • To explore the implications of IP6's interaction with hydroxy-apatite crystal growth for bone formation and overall bone health.
  • To synthesize current understanding regarding the diverse biological activities and health benefits of IP6 and its metabolites.

Main Methods:

  • Review of existing scientific literature on myo-inositol hexaphosphate (IP6) and its effects on crystal formation and biological processes.
  • Analysis of studies examining IP6's interaction with hydroxy-apatite (HA) and calcium oxalate crystals.
  • Evaluation of research concerning IP6's impact on physiological mineralization and bone formation.

Main Results:

  • Myo-inositol hexaphosphate (IP6) effectively binds to hydroxy-apatite and calcium oxalate crystal growth sites, inhibiting pathological calcification.
  • Clinical studies are evaluating hexasodium IP6 (SNF472) for treating vascular calcification and calciphylaxis.
  • While IP6 can inhibit crystal growth, its potential to inhibit essential physiological mineralization in bone formation requires careful consideration, though some studies suggest a positive contribution to bone health.

Conclusions:

  • Myo-inositol hexaphosphate (IP6) demonstrates a complex role, capable of preventing pathological calcification while potentially impacting bone mineralization.
  • Understanding the precise effects of IP6 on bone health is crucial, given its diverse biological activities and potential health benefits.
  • Further research is warranted to elucidate the net impact of dietary IP6 on bone physiology and overall health.