Related Experiment Video
Updated: May 10, 2026
08:43
An Orthotopic Bladder Tumor Model and the Evaluation of Intravesical saRNA Treatment
Published on: July 28, 2012
14.7K
Raman Spectroscopy for Instant Bladder Tumor Diagnosis: System Development and In Vivo Proof-Of-Principle Study in
Ines Latka1, Karin Mogensen2, Florian Knorr1
1Leibniz-Institute of Photonic Technology (IPHT), Leibniz-Health-Technologies, Leibniz-Center for Photonics in Infection Research (LPI), Albert-Einstein-Str. 9, 07745 Jena, Germany.
Cancers
|September 28, 2024
Summary
This study introduces invaScope, an in vivo Raman endoscopy system for bladder cancer detection. It successfully correlated Raman spectroscopy data with histopathology, paving the way for clinical use.
Area of Science:
- Biomedical Optics
- Medical Device Engineering
- Urological Oncology
Background:
- Raman spectroscopy offers label-free molecular fingerprinting of tissues.
- In vivo applications require robust systems compliant with medical regulations.
- Previous ex vivo studies validated the potential of Raman spectroscopy for bladder tissue analysis.
Purpose of the Study:
- To report on the invaScope system, an in vivo Raman-based endoscopy device for bladder tissue analysis.
- To assess the clinical feasibility and usability of the invaScope system in an operating theatre setting.
- To correlate in vivo Raman spectroscopic data with gold-standard histopathological findings.
Main Methods:
- Development and clinical investigation of the invaScope system under European MDR regulations.
- In vivo collection of Raman spectroscopic data from bladder tissues during endoscopic procedures.
- Correlation analysis of Raman data with subsequent histopathological and cytopathological examinations.
Main Results:
- Successful acquisition of in vivo Raman spectra from healthy and tumorous bladder tissues.
- Demonstrated correlation between invaScope-derived Raman signatures and histopathological diagnoses.
- Positive assessment of the system's feasibility and usability in a clinical surgical environment.
Conclusions:
- The invaScope system represents a significant advancement for in vivo bladder lesion characterization using Raman spectroscopy.
- The study confirms the potential for routine clinical application of Raman spectroscopy in urology.
- Further development and validation could lead to improved diagnostic accuracy in bladder cancer detection.
