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Lactase insufficiency revisited.

P Forget, J Lombet, C Grandfils

    Journal of Pediatric Gastroenterology and Nutrition
    |December 1, 1985
    PubMed
    Summary
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    Defining lactase insufficiency in children is crucial. This study establishes a new threshold for primary lactase insufficiency in children with normal small bowel histology, identifying it below 0.75 U/g wet weight based on lactose breath hydrogen test results.

    Area of Science:

    • Pediatric Gastroenterology
    • Digestive Health
    • Biochemistry

    Background:

    • The definition of insufficient small bowel lactase activity lacks consensus.
    • Accurate diagnosis of lactase insufficiency is vital for pediatric health management.

    Purpose of the Study:

    • To redefine primary lactase insufficiency in children.
    • To establish a quantitative threshold for lactase activity in normal small bowel histology.

    Main Methods:

    • Comparison of intestinal lactase activity assays with lactose breath hydrogen test results.
    • Analysis of small bowel biopsies for histology and enzyme activity.
    • Evaluation of sucrase and maltase activity in study cohorts.

    Main Results:

    Related Experiment Videos

    • A threshold of less than 0.75 U/g wet weight for small bowel lactase activity was identified for primary lactase insufficiency.
    • Children with primary lactase insufficiency demonstrated significantly lower lactase activity compared to normal controls.
    • Sucrase and maltase activities were comparable between groups, indicating specificity of lactase deficiency.

    Conclusions:

    • Children with normal small bowel histology and lactase activity below 0.75 U/g wet weight should be diagnosed with primary lactase insufficiency.
    • This quantitative definition aids in standardizing the diagnosis of pediatric lactase insufficiency.
    • The findings support the use of the lactose breath hydrogen test in conjunction with lactase activity levels for accurate diagnosis.