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Updated: Jun 11, 2025
09:44
Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction
Published on: January 29, 2019
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Immunological effects of radiopharmaceutical therapy
Amanda G Shea1, Malick Bio Idrissou2, Ana Isabel Torres1
1Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States.
Frontiers in Nuclear Medicine
|October 2, 2024
Summary
Radiopharmaceutical therapy (RPT) offers a way to treat metastatic cancers by targeting all disease sites. This review explores RPT
Area of Science:
- Oncology and Immunology
- Radiopharmaceutical Therapy Research
Background:
- Radiation therapy (RT) is a standard cancer treatment, but external beam radiation therapy (EBRT) has limitations in treating widespread metastatic disease due to toxicity concerns.
- Radiopharmaceutical therapy (RPT) presents an alternative for irradiating all metastatic sites, but its impact on the immune system and anti-tumor immunity requires careful consideration.
Purpose of the Study:
- To review the immunomodulatory effects of alpha- and beta-particle emitter-based RPT on key immune cell populations.
- To discuss Auger electron-emitter (AEE)-based RPT and its potential implications.
- To explore the synergistic potential of combining RPT with immunotherapies, such as immune checkpoint inhibitors, for metastatic cancers.
Main Methods:
- Literature review focusing on the immunomodulatory effects of different types of RPT.
- Analysis of RPT's impact on T cells (CD8+ and CD4+), natural killer (NK) cells, and regulatory T (Treg) cells.
- Examination of combined RPT and immunotherapy strategies.
Main Results:
- RPT influences various immune cell lines, affecting anti-tumor immunity.
- Understanding these immune effects is critical for managing hematological toxicities associated with RPT.
- Combinations of RPT with immune checkpoint inhibitors show promise for enhanced therapeutic outcomes in metastatic cancers.
Conclusions:
- RPT has significant immunomodulatory effects that must be understood for effective clinical application.
- Integrating RPT with immunotherapies may provide synergistic benefits for patients with advanced metastatic disease.
- Further research into RPT's immune interactions is essential for optimizing cancer treatment strategies.
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