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Related Concept Videos

Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
Modified-Release Drug Delivery Systems: Overview01:19

Modified-Release Drug Delivery Systems: Overview

Modified-release dosage forms are designed to address the limitations of drugs with short biological half-lives. These forms maintain stable therapeutic drug concentrations over extended periods, reducing the need for frequent dosing. A consistent drug level helps minimize peak-trough fluctuations, which can reduce adverse effects, lower the risk of drug resistance, and improve overall treatment effectiveness.One common type of modified-release form is the extended-release (ER) formulation. ER...
Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices01:28

Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices

Parenteral drug delivery systems play a crucial role in modern therapeutics by enabling the direct administration of drugs into the systemic circulation, bypassing the gastrointestinal tract. These systems are particularly valuable for poorly absorbed oral medications that are unstable in the digestive environment or require rapid onset or sustained therapeutic levels. Delivery is achieved through intravenous, intramuscular, or subcutaneous routes, each selected based on the drug's properties...
Intrauterine Drug Delivery Systems01:21

Intrauterine Drug Delivery Systems

Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...

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Related Experiment Video

Updated: Jul 19, 2026

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays
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Optimizing Microfluidic Channel Design with High-Performance Materials for Safe Neonatal Drug Delivery.

T Archana1, N Nachammai1, S Praveenkumar2

  • 1Department of Electronics and Instrumentation Engineering, Annamalai University, Annamalai Nagar, Chidambaram, India.

Recent Advances in Drug Delivery and Formulation
|October 2, 2024
PubMed
Summary

This study evaluated materials and microfluidic channel designs for neonatal drug delivery, finding PDMS to be a feasible solution. Optimized designs enhance drug delivery efficiency and safety for neonates.

Keywords:
Microchannel geometriesMicrofluidic devices.consistent administrationdrug flow ratesintravenous therapiesneonatal patients

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Last Updated: Jul 19, 2026

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Area of Science:

  • Biomedical Engineering
  • Materials Science

Background:

  • Designing microfluidic channels for neonatal drug delivery demands careful consideration of efficiency and safety.
  • Optimizing material selection and channel geometry is crucial for effective neonatal drug administration.

Purpose of the Study:

  • To evaluate high-performance materials for microfluidic neonatal drug delivery.
  • To optimize microfluidic channel design through modeling and simulation for a target flow rate of 0.3-1 mL/hr.

Main Methods:

  • Materials evaluated included PDMS, glass, COC, PMMA, PC, TPE, and hydrogels.
  • COMSOL Multiphysics was used for simulation, analyzing fluid behavior in various channel geometries.
  • Material assessment focused on biocompatibility (ISO 10993), mechanical properties, chemical resistance, and ease of fabrication.

Main Results:

  • PDMS demonstrated flexibility and ease of simulation.
  • Optimized channel designs derived from COMSOL simulations showed improved efficiency.
  • PDMS emerged as a feasible material for neonatal drug delivery applications.

Conclusions:

  • This comparative study guides material and design selection for safer, enhanced neonatal microfluidic drug delivery.
  • The findings support the development of reliable drug delivery systems for neonates.