Drug Abuse and Addiction: Pharmacological Phenomena
Desensitization and Tachyphylaxis
Drug Dependence
Combined Effects of Drugs: Antagonism
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Updated: Jun 11, 2025

A Procedure to Study Stress-Induced Relapse of Heroin Seeking after Punishment-Imposed Abstinence
Published on: March 23, 2022
Shannon C Miller1, Sharon Levy, Andrew J Saxon
1From the Mental Health Service, VA Medical Center, Dayton/Middletown, OH (SCM); Departments of Psychiatry & Population and Public Health Sciences, Boonshoft School of Medicine, Wright State University, Dayton, OH (SCM); Division of Addiction Medicine, Boston Children's Hospital, Boston, MA (SL); Department of Pediatrics, Harvard Medical School, Boston, MA (SL); Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA (AJS); Center of Excellence in Substance Addiction Treatment and Education, VA Puget Sound Health Care System, Seattle, WA (AJS); Program in Addiction Medicine, Yale School of Medicine, New Haven, CT (JMT); Division of Addiction Psychiatry, Department of Psychiatry and Behavioral Health, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY (RNR); Department of Medicine, Harvard Medical School, Boston, MA (SW); Program in Substance Use and Addiction Services, Massachusetts General Hospital, Boston, MA (SW); and Friends Research Institute, Baltimore, MD (FV).
Early intervention for harmful substance use is crucial. Researchers suggest "unhealthy substance use" is a better term than "preaddiction" for identifying individuals needing support, but barriers exist.
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