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Fractures: Bone Repair

Fractures: Bone Repair

Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...

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Updated: Jun 28, 2026

A Method to Estimate Cadaveric Femur Cortical Strains During Fracture Testing Using Digital Image Correlation

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Published on: September 14, 2017

Fracture Risk Prediction Using the Fracture Risk Assessment Tool in Individuals With Cancer.

Carrie Ye¹, William D Leslie², Saeed Al-Azazi²

¹Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.

|October 3, 2024

Summary

This summary is machine-generated.

The Fracture Risk Assessment Tool (FRAX) with bone mineral density (BMD) effectively predicts major osteoporotic and hip fractures in cancer patients. This tool demonstrates good accuracy, making it reliable for assessing fracture risk in this population.

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Published on: September 27, 2024

Area of Science:

Oncology
Geriatrics
Epidemiology

Background:

The Fracture Risk Assessment Tool (FRAX) predicts major osteoporotic fracture (MOF) and hip fracture risk in the general population.
Its utility in individuals with cancer remains uncertain, necessitating further investigation.

Purpose of the Study:

To evaluate the performance of FRAX, incorporating bone mineral density (BMD), in predicting incident fractures among cancer patients.

Main Methods:

A retrospective, population-based cohort study in Manitoba, Canada (1987-2014) included 9,877 cancer patients and 45,877 controls.
FRAX scores were calculated using BMD data from the Manitoba BMD Registry.
Incident fractures were tracked through healthcare data until March 2021.

Main Results:

Cancer patients exhibited higher rates of incident MOF (14.5 vs 12.9 per 1000 person-years) and hip fractures (4.2 vs 3.5 per 1000 person-years) compared to controls.
In the cancer cohort, FRAX with BMD was significantly associated with incident MOF (HR 1.84) and hip fractures (HR 3.61).
Calibration slopes for FRAX with BMD were 1.03 for MOF and 0.97 for hip fractures, indicating good model fit.

Conclusions:

FRAX incorporating BMD demonstrates strong predictive performance, with good stratification and calibration for incident fractures in cancer patients.
These findings support the use of FRAX with BMD as a reliable tool for fracture risk assessment in individuals diagnosed with cancer.