[Effect of lithium, carbamazepine, ca-valproate and diazepam on changes in social isolation-induced behavior in mice]

Neurobiological changes induced by social isolation of mice are used to characterize pharmacological influences of lithium and several other drugs. Lithium is able to prevent not only early serotoninergic changes but also enhanced aggressiveness and enhanced spontaneous locomotion, seen after long term isolation. Very similar to lithium are the effects of carbamazepine, whereas Ca-valproat and diazepam prevent the early serotoninergic (stress like) changes, but not later changes in aggressivity and locomotion.