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Related Concept Videos

Embryonic Stem Cells00:57

Embryonic Stem Cells

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
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Stem Cell Culture01:17

Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Related Experiment Video

Updated: Jun 11, 2025

Protocol for Human Blastoids Modeling Blastocyst Development and Implantation
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Early human development and stem cell-based human embryo models.

Marta N Shahbazi1, Vincent Pasque2

  • 1MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.

Cell Stem Cell
|October 4, 2024
PubMed
Summary
This summary is machine-generated.

Stem cells offer a new way to study the first two weeks of human embryo development, revealing insights into developmental biology and reproduction. This research explores stem cell derivation and in vitro modeling of early human embryogenesis.

Keywords:
human embryospluripotent stem cellsstem cell-based embryo models

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Area of Science:

  • Developmental Biology
  • Stem Cell Research
  • Human Reproduction

Background:

  • Early human embryo development is crucial for understanding reproduction.
  • Stem cells provide a unique window into these initial developmental stages.

Purpose of the Study:

  • To review current knowledge of the first two weeks of human embryo development.
  • To discuss the use of stem cells in modeling early embryogenesis.
  • To highlight advances and future directions in stem cell-based embryo models.

Main Methods:

  • Review of existing literature on human embryogenesis and stem cell biology.
  • Analysis of stem cell derivation techniques.
  • Discussion of in vitro recapitulation of intercellular signaling pathways.

Main Results:

  • Identification of distinct embryonic cell lineages and stem cell types.
  • Understanding of key intercellular communication guiding development.
  • Demonstration of in vitro stem cell-based models mimicking early embryogenesis.

Conclusions:

  • Stem cell models are transforming the study of early human development.
  • Further research is needed to address current limitations in in vitro modeling.
  • Future work will enhance our understanding of developmental biology and reproductive health.