[The impact of maternal smoking during pregnancy on respiratory disease in children]
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Updated: Jun 11, 2025

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
Published on: August 25, 2014
1Dynamicure Inserm UMR 1311, FHU Respire, département de pédiatrie médicale, CHU de Rouen, université Rouen Normandie, 76000 Rouen, France.
Insights
Maternal smoking during pregnancy significantly harms fetal lung development, leading to respiratory issues like prematurity and infections. Emerging evidence also points to risks from e-cigarette use for infant respiratory health.
Area of Science:
- Obstetrics and Gynecology
- Pediatrics
- Environmental Health
Context:
- Maternal smoking is a significant global health concern, with varying prevalence rates during pregnancy worldwide.
- Abnormal fetal lung development is linked to various factors, with maternal smoking being a key preventable cause.
- Understanding the impact of maternal smoking on fetal and neonatal respiratory health is crucial for public health initiatives.
Purpose:
- To review the existing literature on the effects of maternal smoking on fetal and neonatal lung development.
- To identify the short-term and long-term respiratory consequences for infants and children exposed to maternal smoking in utero.
- To highlight the emerging risks associated with electronic cigarette use during pregnancy.
Summary:
- Maternal smoking during pregnancy leads to adverse fetal lung development, increasing the risk of prematurity and subsequent bronchopulmonary dysplasia.
- Infants exposed to maternal smoking are more susceptible to respiratory infections, particularly in early childhood.
- Long-term effects include an increased likelihood of developing asthma, allergies, and impaired respiratory function in children and adolescents.
- Electronic cigarettes (e-cigarettes) pose a potential emerging threat to the respiratory health of fetuses and neonates.
Impact:
- Provides critical insights for preventive medicine strategies targeting maternal smoking cessation.
- Informs healthcare providers about the long-term respiratory health risks associated with prenatal smoke exposure.
- Highlights the need for further research and public health awareness regarding e-cigarette use during pregnancy.
Abstract:
Among the causes of abnormal fetal lung development, active and environmental maternal smoking represents a major potential target in preventive medicine. Prevalence of smoking among women, particularly during pregnancy, varies across the different regions of the world. We reviewed the literature on the repercussions of maternal smoking on the lungs of the fetus and the neonate. One of the main consequences is prematurity, leading to pulmonary bronchodysplasia followed by respiratory infections, which particularly affect young children. In the medium- and long-term, smoking in utero leads to asthma and allergies, and is suspected to be associated with impaired respiratory function in children and teenagers. We also report on the potential effects of e-cigarettes, which represent an emerging threat to children's respiratory health.
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