Roles of noncoding RNA in allergic rhinitis

Area of Science:

• Biochemistry
• Molecular Biology
• Immunology

Background:

• Allergic rhinitis (AR) is a prevalent, increasing respiratory disease characterized by inflammation, hyperreactivity, and mucus hypersecretion.
• AR arises from genetic and environmental factors, involving complex cellular responses.
• Noncoding RNAs (ncRNAs), such as microRNAs (miRNAs), long ncRNAs (lncRNAs), and circular RNAs (circRNAs), regulate gene expression and are implicated in various diseases.

Purpose of the Study:

• To review the expression and function of ncRNAs in AR.
• To explore the role of ncRNAs as potential biomarkers for AR diagnosis, surveillance, and prognosis.
• To discuss the therapeutic potential and interactions of ncRNAs in AR.

Main Methods:

• Literature review of studies on ncRNAs and respiratory allergic diseases.
• Analysis of ncRNA expression, function, and interactions in AR pathogenesis.
• Inclusion of high-quality studies and consideration of author expertise.

Main Results:

• ncRNAs serve as valuable biomarkers for early AR diagnosis, disease monitoring, and prognosis.
• Different ncRNA categories exhibit distinct but interconnected roles in gene regulatory networks.
• ncRNAs are also identified as therapeutic targets and biomarkers in other allergic conditions.

Conclusions:

• ncRNAs possess broad applications in AR treatment, encompassing miRNAs, lncRNAs, and circRNAs.
• Future research directions focus on practical clinical applications of ncRNAs as therapeutic targets and biomarkers.
• Advancements in research and technology may lead to novel and effective AR treatment strategies utilizing ncRNAs.