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Potential Role of Sleep Disturbance in the Development of Early Puberty: Past Clinical Evidence for Future Management

Dolrutai Puttawong1, Karn Wejaphikul1, Chanisa Thonusin2

  • 1Faculty of Medicine, Division of Pediatric Endocrinology and Metabolism, Department of Pediatrics, Chiang Mai University, Chiang Mai, Thailand.

Pediatric Neurology
|October 5, 2024
PubMed

Insights

Early puberty is rising, with sleep disturbances potentially accelerating its onset. This review explores the link between sleep and puberty, offering insights for future treatments.

Area of Science:

  • Pediatrics
  • Endocrinology
  • Sleep Medicine

Background:

  • Increasing incidence of early puberty in children.
  • Suspected influence of genetic and environmental factors (nutrition, hormones).
  • Emerging evidence links sleep patterns to pubertal development.

Purpose of the Study:

  • To comprehensively review the association between sleep disturbance and early puberty.
  • To discuss findings, including contrary evidence.
  • To explore potential therapeutic implications.

Main Methods:

  • Literature review of studies on sleep and puberty.
  • Analysis of hormonal markers like luteinizing hormone (LH).
  • Examination of prevalence in sleep disorder patients.

Main Results:

  • Luteinizing hormone (LH) increases during deep sleep, a puberty marker.
  • Higher prevalence of early puberty observed in individuals with sleep disorders, notably narcolepsy.
  • Existing research indicates a significant correlation between sleep disruption and precocious puberty.

Conclusions:

  • Sleep disturbance is a key factor associated with early puberty.
  • Understanding this link can inform future therapeutic strategies for central precocious puberty.
  • Further research into sleep's role may offer novel treatment options.

Keywords:
Early pubertyHypocretinOrexinPrecocious pubertySleep disturbance

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