Related Experiment Videos
[Tinnitus therapy with lidocaine and tocainide].
Laryngologie, Rhinologie, Otologie
|December 1, 1985
Summary
Lidocaine infusion effectively treated tinnitus in 70% of patients, while oral tocainide showed limited success due to side effects. A lidocaine test can guide tocainide therapy for severe tinnitus cases.
Area of Science:
- Otolaryngology
- Clinical Pharmacology
Background:
- Tinnitus is a challenging condition often associated with sensory hearing loss.
- Effective treatments for intractable tinnitus remain limited.
Purpose of the Study:
- To evaluate the therapeutic efficacy of lidocaine and tocainide (infusion and oral) compared to placebo for tinnitus treatment.
- To explore patient selection criteria for tocainide therapy.
Main Methods:
- A randomized clinical cross-over study involving 40 patients with constant, intractable tinnitus and sensory hearing loss.
- Comparison of lidocaine infusion, tocainide infusion, oral tocainide, and placebo treatments.
- Assessment of tinnitus suppression and side effects.
Main Results:
- Lidocaine infusion achieved >50% tinnitus suppression in approximately 70% of patients.
- Tocainide infusion was effective in 55% of patients, while oral tocainide succeeded in only 35%.
- A significant proportion of side effects limited oral tocainide use.
Conclusions:
- Lidocaine infusion demonstrates significant therapeutic value for tinnitus.
- Oral tocainide therapy is recommended only for severely affected patients who respond positively to a lidocaine test.
- Careful patient selection and consideration of side effects are crucial for tocainide treatment.