Related Experiment Video
Updated: Jun 11, 2025
03:05
Author Spotlight: Advancing Early Detection and Treatment of Gastrointestinal Tumors
Published on: February 16, 2024
983
Isolated Gastric Crohn's Disease: A Growing Tendency
Rebal Nahas1, Chakib Khoury1, Emanuel Youssef Dib1
1Department of Internal Medicine, University of Balamand, Beirut, Lebanon.
European Journal of Case Reports in Internal Medicine
|October 7, 2024
Summary
Isolated gastric Crohn's disease (IGCD) is rare, presenting unique diagnostic challenges. This case shows successful management with infliximab, highlighting the need for individualized treatment plans for unexplained gastric symptoms.
Area of Science:
- Gastroenterology
- Inflammatory Bowel Disease
- Digestive System Disorders
Background:
- Isolated gastric Crohn's disease (IGCD) is an uncommon form of Crohn's disease affecting only the stomach.
- It often presents with non-specific epigastric symptoms, mimicking other gastric pathologies.
- Diagnosis can be challenging due to its rarity and atypical presentation.
Purpose of the Study:
- To report a case of IGCD in a young female.
- To discuss the diagnostic workup and management strategies for IGCD.
- To emphasize the importance of considering IGCD in patients with unexplained gastric symptoms.
Main Methods:
- A 25-year-old female presented with epigastric discomfort and nausea.
- Diagnostic procedures included upper endoscopy with biopsies and serological tests (ASCA, p-ANCA).
- Treatment involved prednisone for acute symptoms and infliximab for maintenance therapy.
Main Results:
- Endoscopy revealed gastric ulceration; biopsies showed non-caseating granulomas.
- IGCD diagnosis was confirmed by positive ASCA and negative p-ANCA, with no ileal or colonic involvement.
- The patient achieved symptom resolution and remained relapse-free during follow-up.
Conclusions:
- IGCD presents diagnostic complexities requiring a high index of suspicion.
- Serological markers like ASCA and p-ANCA aid in differentiating Crohn's disease.
- Individualized treatment is crucial given the lack of specific IGCD guidelines, with biologics like infliximab showing promise.
Related Concept Videos
01:30Inflammatory Bowel Disease II: Crohn's Disease
194
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
194
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
323
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
323
01:17Chronic Bowel Disorders: Introduction
403
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
403
01:17Gastritis-II: Pathophysiology
269
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
269
01:27Gastritis-I: Introduction and Types
289
Gastritis, defined by the inflammation or irritation of the stomach lining or gastric mucosa, manifests in several distinct forms: acute, chronic, reactive, and a specific subtype known as autoimmune metaplastic atrophic gastritis.
Acute gastritis presents as a sudden inflammation triggered by various stressors to the stomach lining, such as exposure to corrosive agents, local irritants like aspirin and other NSAIDs, alcohol consumption, radiation therapy, physical trauma, severe burns, sepsis,...
Acute gastritis presents as a sudden inflammation triggered by various stressors to the stomach lining, such as exposure to corrosive agents, local irritants like aspirin and other NSAIDs, alcohol consumption, radiation therapy, physical trauma, severe burns, sepsis,...
289
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
148
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
148