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Adrenal Gland Disorders01:27

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Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
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Gut microbiota causally impacts adrenal function: a two-sample mendelian randomization study.

Tonghu Liu1,2,3, Hongfei Ji4, Zhiyuan Li1,2,3

  • 1Department of Urology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450001, Henan, People's Republic of China.

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|October 7, 2024
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Summary
This summary is machine-generated.

The gut microbiota causally influences adrenal gland function, impacting hormone levels. This research clarifies the gut-microbiota-brain axis, aiding in adrenal disease diagnosis and treatment.

Keywords:
Adrenal functionCausal inferenceGut microbiotaGut-microbiota-brain axisMendelian randomization

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Area of Science:

  • Microbiology
  • Endocrinology
  • Genetics

Background:

  • Gut microbiota's influence on adrenal hormones is suggested but not causally established.
  • Understanding the gut-microbiota-adrenal axis is crucial for endocrine health.

Purpose of the Study:

  • To systematically investigate the causal impact of gut microbiota on adrenal gland function using Mendelian randomization.
  • To identify specific gut bacteria associated with adrenal function across different zones.

Main Methods:

  • A two-sample Mendelian randomization (MR) study utilizing genome-wide association study (GWAS) summary statistics.
  • Inverse variance weighting (IVW) as the primary analysis method, with MR-Egger, weighted median, and cML-MA for robustness.
  • Sensitivity analyses including MR-Egger intercept, Cochran's Q test, and leave-one-out analysis to assess pleiotropy and heterogeneity.

Main Results:

  • Identified 27 significant causal relationships between 23 gut microbes and adrenal function.
  • Sellimonas was found to enhance adrenal cortex reticularis zone function (beta=0.008, P=0.0057).
  • Parasutterella, Sutterella, and Anaerofilum were associated with the function of different adrenal regions. No significant pleiotropy was detected.

Conclusions:

  • Gut microbiota composition causally affects adrenal gland function.
  • Findings support the gut-microbiota-brain axis and offer insights for clinical applications in adrenal diseases.
  • This study provides a foundation for targeted interventions involving gut microbiota for adrenal health.