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Assessment of Vascular Function in Patients With Chronic Kidney Disease
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Assessment of Vascular Function in Patients With Chronic Kidney Disease

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Assessing renal function as a predictor of adverse outcomes in diabetic patients undergoing percutaneous coronary

Farima Sadat Mousavi1, Babak Bagheri1, Rozita Jalalian1

  • 1Department of Cardiology, Faculty of Medicine, Cardiovascular Research Center, Mazandaran University of Medical Sciences, Sari, Iran.

Acta Cardiologica
|October 8, 2024
PubMed

Insights

Diabetic patients with severe chronic kidney disease (CKD) undergoing percutaneous coronary intervention (PCI) face significantly higher risks of mortality, major adverse cardiovascular events (MACE), and triple vessel disease (TVD). Optimizing renal function is crucial for managing these high-risk patients.

Area of Science:

  • Cardiology
  • Nephrology
  • Diabetology

Background:

  • Cardiovascular diseases are a leading cause of death, especially in diabetic patients post-percutaneous coronary intervention (PCI).
  • Chronic kidney disease (CKD) is an additional risk factor in this population, but its impact on outcomes like major adverse cardiovascular events (MACE), mortality, and triple vessel disease (TVD) after PCI is debated, particularly in type 2 diabetes mellitus (T2DM).

Purpose of the Study:

  • To investigate the influence of renal function on MACE, mortality, and TVD in diabetic patients undergoing PCI.
  • To assess the association between varying degrees of CKD and cardiovascular outcomes post-PCI.

Main Methods:

  • Analysis of diabetic patients undergoing PCI, stratified by glomerular filtration rate (GFR) to assess renal function.
  • Logistic regression and receiver operating characteristic (ROC) analysis were employed to determine associations and predictive values.

Main Results:

  • Severe CKD was significantly linked to increased odds of 1-month mortality (OR: 15.694), 1-month MACE (OR: 7.734), and TVD (OR: 3.740).
  • Patients with severe CKD also showed higher odds of 6-month mortality (OR: 12.192) and 6-month MACE (OR: 3.848).
  • GFR demonstrated significant predictive accuracy for mortality at both 1- and 6-month follow-ups (AUC: 0.77 and 0.71, respectively).

Conclusions:

  • Renal dysfunction, especially severe CKD, substantially increases the risk of MACE, mortality, and TVD in diabetic patients post-PCI.
  • Implementing strategies to optimize renal function and personalize cardiovascular management is essential for improving outcomes in this vulnerable patient group.
Abstract

Keywords:
Major adverse cardiovascular eventschronic kidney diseasediabetes

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