Related Experiment Video
Updated: Jun 11, 2025

A Murine Model of Muscle Training by Neuromuscular Electrical Stimulation
Published on: May 9, 2012
Influence of vitamin D on muscle strength and botulinum toxin dosage through surface electromyography
Marcelle Simões Coelho1, Gabriel Cirone Lopes1, Luigi Giovanni Bernardo Sichi1
1Universidade Estadual Paulista "Júlio de Mesquita Filho" - Dental Materials and Prosthesis Departament - São José dos Campos (SP) - Brazil.
Purpose:
To evaluate the influence of patients' serum vitamin D levels on muscle strength characteristics and whether it impacts the durability of botulinum toxin (BT) treatment.
Methods:
The muscle strength of the frontal and corrugator muscles was evaluated before and after the application of TB with pre- and post-application control measurements, and at weeks 2, 5 and 12. The effect of vitamin D on muscle strength and its interaction with BT were investigated in 20 patients. The muscle contraction force was measured by surface electromyography.
Results:
The results revealed statistically significant differences between the frontal measurement groups at weeks 2 and 5, as well as for the corrugator in the same weeks and at week 12. Regarding vitamin D, significant differences were observed only in the initial group with vitamin D > 30 ng/mL compared to < 30 ng/mL for the frontal muscles. Patients with higher levels of vitamin D had higher average muscle strength compared to those with lower levels in all evaluations.
Conclusions:
It was observed that vitamin D influences muscle strength and the necessary dosage of BT.
Related Concept Videos
Directly Acting Muscle Relaxants: Dantrolene and Botulinum Toxin
The binding of dantrolene to the RYR1...
Myasthenia Gravis: Diagnostic Tests
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
Muscle Stimulation Frequency
Wave summation
At low firing rates, motor neurons induce individual twitch contractions in muscle fibers. These twitches...
Skeletal Muscle Relaxants: Therapeutic Uses
Motor Unit Stimulation
The latent period of contraction marks the onset of excitation-contraction coupling, when the action potential propagates across the sarcolemma, preparing the muscle fibers for contraction. As the fibers enter the contraction phase, the...
Skeletal Muscle Relaxants: Adverse Effects
Unlike...

