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Skin Diseases and Disorders

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...

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Related Experiment Video

Updated: Jun 11, 2025

Author Spotlight: Enhancing Candida albicans Detection in Catheter Infections Using Fluorescent Protein Tagging

Author Spotlight: Enhancing Candida albicans Detection in Catheter Infections Using Fluorescent Protein Tagging

Published on: March 22, 2024

[Invasive candidiasis].

Julie Dudler¹, Christian Chuard²

¹Service de médecine interne, HFR Fribourg, 1752 Villars-sur-Glâne.

Revue Medicale Suisse

|October 10, 2024

Summary

This summary is machine-generated.

Invasive fungal infections are primarily caused by Candida species, with diagnosis relying on blood cultures and other methods. Management involves antifungals and source control, though multidrug-resistant Candida auris poses a significant challenge.

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Area of Science:

Mycology
Infectious Diseases
Clinical Microbiology

Context:

Candida species cause 70-90% of invasive fungal infections.
Invasive candidiasis diagnosis relies on blood cultures, supplemented by PCR, beta-D-glucans, mannans/anti-mannans, and clinical scores like the Candida score.
Candida albicans is prevalent in Switzerland, generally susceptible to antifungals.

Purpose:

To review the diagnosis and management of invasive candidiasis.
To highlight the challenges posed by multidrug-resistant Candida auris.

Summary:

Invasive candidiasis is diagnosed via blood culture, with adjunctive methods like PCR and biomarkers available.
Treatment involves antifungal therapy, catheter removal, source control, and monitoring for complications such as endophthalmitis.
The emergence of multidrug-resistant Candida auris presents a significant public health concern due to its high transmissibility and resistance.

Impact:

Improved understanding of diagnostic and management strategies for invasive candidiasis.
Increased awareness of the threat posed by multidrug-resistant Candida auris, necessitating enhanced infection control measures.
Guidance for clinicians in managing Candida infections, particularly in the context of emerging resistance patterns.