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Effect of the Communities That HEAL Intervention on Overdose Education and Naloxone Distribution: A
Patricia R Freeman1, Alexander Y Walley1, T John Winhusen1
1Patricia R. Freeman and Douglas R. Oyler are with the University of Kentucky College of Pharmacy, Department of Pharmacy Practice and Science, Lexington. Alexander Y. Walley, Trevor J. Baker, and Jeffrey H. Samet are with the Boston Medical Center, Boston, MA. T. John Winhusen is with the University of Cincinnati Department of Psychiatry and Behavioral Neuroscience, Cincinnati, OH. Emmanuel A. Oga, Christian Douglas, JaNae Holloway, Nathan A. Vandergrift, Joella W. Adams, Katherine Asman, LaShawn M. Glasgow, Charles Knott, and Gary A. Zarkin are with RTI International, Research Triangle Park, NC. Jennifer Villani and Redonna K. Chandler are with the National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD. Timothy Hunt, Kitty Gelberg, James L. David, Louisa Gilbert, Dawn A. Goddard-Eckrich, and Nabila El Bassel are with the Columbia University School of Social Work, Social Intervention Group, New York, NY. Brittni Reilly is with the Massachusetts Department of Public Health, Boston. Michael S. Lyons is with Ohio State University Department of Emergency Medicine, Columbus. Candace J. Brancato is with the University of Kentucky College of Public Health, Department of Biostatistics, Lexington. Debbie M. Cheng is with the Boston University School of Public Health, Department of Biostatistics, Boston, MA. Janet E. Childerhose is and Rebecca D. Jackson was with the Ohio State University College of Medicine, Department of Internal Medicine, Columbus. Daniel J. Feaster is with the University of Miami Miller School of Medicine, Department of Public Health Sciences, Miami, FL. Hannah K. Knudsen, Michelle R. Lofwall, Katherine R. Marks, and Sharon L. Walsh are with the University of Kentucky College of Medicine, Department of Behavioral Science, Lexington. Jason T. McMullan is with the University of Cincinnati Department of Emergency Medicine, Cincinnati, OH. Carrie B. Oser is with the University of Kentucky, Department of Sociology, Lexington. Monica Roberts and Josie Watson are with the University of Kentucky Substance Use Priority Research Area, Lexington. Abigail B. Shoben is with the Ohio State University College of Public Health, Division of Biostatistics, Columbus. Michael D. Stein is with the Boston University School of Public Health, Department of Health Law, Policy, and Management, Boston, MA. Scott T. Walters is with the University of North Texas Health Science Center, School of Public Health, Fort Worth.
None:
Objectives. To determine whether the Communities That HEAL (CTH) intervention is effective in increasing naloxone distribution compared with usual care. Methods. The HEALing (Helping to End Addiction Long-Term) Communities Study (HCS) is a cluster-randomized, parallel-arm, wait-list controlled implementation science trial testing the impact of the CTH intervention on increasing the use of evidence-based practices to lower opioid-related overdose deaths. Communities (n = 67) highly impacted by opioid overdose in Kentucky, Massachusetts, New York, and Ohio were allocated to CTH intervention (n = 34) or wait-list comparison (usual care; n = 33) arms. The primary outcome for this study was the number of naloxone units distributed in HCS communities during the comparison period (July 1, 2021‒June 30, 2022), examined using an intent-to-treat negative binomial regression model. Results. Naloxone distribution was 79% higher in the CTH intervention versus usual care arm (adjusted relative rate = 1.79; 95% confidence interval = 1.28, 2.51; P = .001; adjusted rates of naloxone distribution 3378 vs 1884 naloxone units per 100 000 residents), when controlling for urban‒rural status, state, baseline opioid-related overdose death rate, and baseline naloxone distribution rate. Conclusions. The CTH intervention increased naloxone distribution compared with usual care in communities highly impacted by the opioid crisis. Trial Registration. ClinicalTrials.gov identifier: NCT04111939. (Am J Public Health. 2025;115(1):83-94. https://doi.org/10.2105/AJPH.2024.307845).
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