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Updated: Jun 10, 2025

Author Spotlight: Regenerative Peripheral Nerve Interface (RPNI) Surgery in Postamputation Pain Management
Published on: March 15, 2024
Postamputation Pain Management
Merideth Byl1, Jennifer Tram1, Brandon Kalasho1
1Department of Physical Medicine & Rehabilitation, Greater Los Angeles Veteran Affairs HealthCare System, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA; Division of PM&R, Department of Medicine, 200 UCLA Medical Plaza, Suite 420, Los Angeles, CA 90095, USA.
None:
Postamputation pain is one of the most common and challenging pain conditions to treat and includes residual limb pain and phantom limb pain. Residual limb pain is present at the amputation site or proximal to the amputation site and may be caused by poor wound healing, poor prosthetic fitting, or neuropathic pain. Phantom limb pain is experienced distal to the amputation site and may be caused by maladaptive supraspinal reorganization. Treatment for post amputation pain should be multimodal and multidisciplinary, including pharmacologic agents, rehabilitation, psychosocial support, and integrative therapies. Surgical interventions including neuromodulation may be considered for refractory cases.
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