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Next-generation Sequencing03:00

Next-generation Sequencing

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The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
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DNA sequencing is a fundamental technique that is routinely used in the biological sciences. This method can be applied to a range of questions at different scales - from the sequencing of a cloned DNA fragment or the study of a mutation in a gene up to whole-genome sequencing. However, despite the widespread use of sequencing today, it was not until 1977 that Fredrick Sanger and his collaborators developed the chain-termination method to decode DNA sequences. It relies on the separation of a...
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Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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In the same year as the discovery of the Sanger sequencing method, another group of scientists, Allan Maxam and Walter Gilbert, demonstrated their chemical-cleavage method for DNA sequencing. The Maxam-Gilbert method relies on using different chemicals that can cleave the DNA sequence at specific sites, the separation of resulting DNA fragments of variable size using electrophoresis, and deciphering the DNA sequence from the resulting gel bands.
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Editorial: The 21st Asian Pacific Bioinformatics Conference 2023.

Min Li, Yi-Ping Phoebe Chen

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    This special issue features ten papers from the 21st Asia Pacific Bioinformatics Conference (APBC). These works highlight recent advancements in bioinformatics research and applications.

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    Area of Science:

    • Bioinformatics
    • Computational Biology
    • Genomics

    Background:

    • The 21st Asia Pacific Bioinformatics Conference (APBC) convened in Changsha, China.
    • This special issue showcases ten selected papers presented at the conference.
    • The conference focused on cutting-edge research in bioinformatics.

    Discussion:

    • The presented papers cover diverse bioinformatics topics.
    • These include computational methods for biological data analysis.
    • The research reflects the dynamic nature of the field.

    Key Insights:

    • Advancements in algorithms for sequence analysis.
    • Novel approaches in structural bioinformatics.
    • Applications of machine learning in biological data interpretation.

    Outlook:

    • Future directions in comparative genomics.
    • Emerging trends in systems biology.
    • The growing impact of bioinformatics on precision medicine.