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Oro-Dental Characteristics in Patients With Adult-Onset Hypophosphatasia Compared to a Healthy Control Group-A
Freja Fribert Jørgensen1, Xenia Hermann2, Nicola Hepp3
1Department of Odontology, Section of Orthodontics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Journal of Oral Rehabilitation
|October 11, 2024
Summary
Adult-onset hypophosphatasia (aHPP) patients report worse dental health, experiencing more tooth fractures, caries, and tooth loss. Findings include tooth opacities and increased distance between the enamel-cement junction and bone.
Area of Science:
- Dentistry
- Genetics
- Metabolic Diseases
Background:
- Hypophosphatasia (HPP) is a rare inherited disorder affecting multiple organ systems.
- Limited research exists on the oral and dental health of individuals with adult-onset HPP (aHPP).
Purpose of the Study:
- To investigate and compare oro-dental characteristics in patients with aHPP versus healthy controls.
Main Methods:
- A case-control study involving 20 aHPP patients and 31 healthy controls.
- Evaluated oro-dental manifestations through standardized interviews, clinical examinations, panoramic radiography, and cone-beam computed tomography (CBCT).
Main Results:
- aHPP patients reported significantly higher rates of tooth fractures, caries, and early permanent tooth loss.
- Observed were lower tooth attrition and specific tooth presence in aHPP patients.
- aHPP patients showed increased tooth opacities, denticles, and a greater distance between the enamel-cement junction (CEJ) and marginal bone level.
Conclusions:
- Patients with aHPP subjectively report poorer dental health.
- Key oro-dental findings in aHPP include tooth loss, reduced attrition, opacities, denticles, and altered bone levels around teeth.
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