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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Radiographic Horizontal Conjugate Gaze Deviation: Clinical Correlates.

Shervin Badihian1, Elias Samaha1, David E Newman-Toker1

  • 1Department of Neurology (SB), Neurological Institute, Cleveland Clinic, OH; Department of Neurology (ES, JCK), University of Illinois College of Medicine, Peoria; and Departments of Neurology (DEN-T, DSZ), Otolaryngology and Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, MD.

Neurology. Clinical Practice
|October 14, 2024
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Summary
This summary is machine-generated.

Radiographic, horizontal, conjugate gaze deviation (Rad h-CGD) aids in diagnosing neurologic and vestibular disorders by correlating ocular findings with lesion location. Understanding Rad h-CGD possibilities improves patient management.

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Area of Science:

  • Neurology
  • Ophthalmology
  • Radiology

Background:

  • Radiographic, horizontal, conjugate gaze deviation (Rad h-CGD) has emerged as a potential marker for various neurologic and vestibular conditions since 2003.
  • Over two decades, clinical correlates linking Rad h-CGD to supratentorial and infratentorial lesions have been identified.

Purpose of the Study:

  • To elucidate the diagnostic value of Rad h-CGD in localizing and lateralizing neurologic and vestibular lesions.
  • To provide clinicians and radiologists with a comprehensive understanding of Rad h-CGD's diagnostic possibilities for improved patient care.

Main Methods:

  • Correlating measured angles of deviation in Rad h-CGD with clinical findings and underlying lesion mechanisms.
  • Reviewing existing literature on lesion localization and integrating it with clinical experience.
  • Developing a practical algorithm for interpreting Rad h-CGD findings.

Main Results:

  • Rad h-CGD provides valuable diagnostic and localization information, potentially revealing subtle ocular findings.
  • The clinical context is crucial as Rad h-CGD alone cannot differentiate between supratentorial and infratentorial lesions.
  • Rad h-CGD can be associated with various conditions including large vessel occlusion strokes, acute vestibular syndrome, and ischemic events in the cerebellum, brainstem, or labyrinth.

Conclusions:

  • Rad h-CGD is a useful tool for diagnosing and localizing neurologic and vestibular disorders.
  • Integrating Rad h-CGD interpretation with clinical context enhances diagnostic accuracy.
  • Further understanding of Rad h-CGD aids in managing a spectrum of central and peripheral nervous system conditions.