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Updated: Jun 10, 2025

Author Spotlight: Unraveling Vitamin A Transport Mechanisms — Linking Liver Receptors to Vision Health Through RBPR2 and RBP4 Interactions
Published on: October 4, 2024
[Decreased vision due to hypovitaminosis A in children with food selectivity]
Natalia Moreno1, Florencia C Lynch1, María A Zalazar1
1Servicio de Nutrición y Diabetes, Hospital de Pediatría S.A.M.I.C. Prof. Dr. Juan P. Garrahan, Buenos Aires, Argentina.
Introduction:
Vitamin A deficiency can cause eye disease and has been related to food selectivity in children with autism spectrum disorder (ASD).
Methods:
A series of 13 pediatric patients with severe ophthalmological involvement as an initial manifestation of hypovitaminosis A is described.
Results:
With significant Vitamin A deficiency, neuroimaging was performed in 11 patients. Of these, 8 had pathological findings with the presence of cranial hyperostosis. Lumbar puncture was performed in these patients and endocranial hypertension was detected in 7 of the 8 patients. All had food selectivity and 61.5% had ASD.
Conclusions:
Toxic-nutritional optic neuropathy is a rare pathology in children and presents with progressive, bilateral and painless visual loss due to damage to the optic nerve, which can generate severe and irreversible damage to it. Food history allows early detection of nutrient deficiencies in children with restrictive feeding, especially in neuro-atypical patients. This is essential to implement preventive measures and treatment with vitamin A in order to avoid irreversible consequences.
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